Background: Researchers from the fields of safety studies and internal medicine (cardiology) conducted a cross-sectional interdisciplinary study aimed at determining the impact of patients’ experiences with various forms of violence, psychological, physical, and digital as well as hazards such as floods, fires, earthquakes, traffic accidents, crime (theft and fraud), and political violence (war) on the onset and progression of cardiovascular diseases. Material and Methods: To assess the relationships between the variables, a quantitative research design was employed. The questionnaire was administered to 302 patients in a pre-operative department. The results of this exploratory study were presented using descriptive statistics, non-parametric analysis (Mann-Whitney U test) and simple linear regression models. Results: The key results highlight a consistent link between all assessed threats to personal safety and adverse cardiovascular outcomes. Statistical analysis, conducted through the combined lens of safety studies and cardiology, underscores the need for further research, particularly into the effects of digital violence, theft, fraud, and traffic accidents on the cardiovascular health of the broader population. Conclusions: Given that a substantial proportion of participants had been involved in traffic accidents and that this experience was statistically linked to cardiovascular conditions, the study highlights an urgent need for further research in this area. Med Pr Work Health Saf. 2026;77(3)