REVIEW PAPER
Nanogold – Biological effects and occupational exposure levels
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Instytut Medycyny Pracy im. prof. J. Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland
(Zakład Bezpieczeństwa Chemicznego / Department of Chemical Safety)
Online publication date: 2017-05-09
Med Pr Work Health Saf. 2017;68(4):545-56
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ABSTRACT
Nanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine,
laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation and
ingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Gold
nanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross the
blood–brain and blood–placenta barriers. Toxicokinetics of nanogold depends on the particle size, shape and surface charge. In
animals exposure to gold nanoparticles via inhalation induces slight changes in the lungs. Exposure to nanogold by the oral route
does not cause adverse health effects in rodents. In animals after injection of gold nanoobjects changes in the liver and lungs were
observed. Nanogold induced genotoxic effects in cells, but not in animals. No adverse effects on the fetus or reproduction were
found. There are no carcinogenicity studies on gold nanoparticles. The mechanism of toxicity may be related to the interaction of
gold nanoobjects with proteins and DNA, and it leads to the induction of oxidative stress and genetic material damage. The impact
of nanostructures on human health has not yet been fully understood. The person, who works with nanomaterials should exercise
extreme caution and apply existing recommendations on the evaluation of nanoobjects exposure. The risk assessment should be
the basis for taking appropriate measures to limit potential exposure to nanometals, including nanogold. Med Pr 2017;68(4):545–556