ORIGINAL PAPER
Fatty liver as a risk factor for cardiovascular diseases: retrospective analysis of data from patients of the Geriatrics Clinic of University Clinical Hospital in Wrocław
More details
Hide details
1
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu / Wroclaw Medical University, Wrocław, Poland (Katedra i Klinika Geriatrii / Department of Geriatrics)
2
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu / Wroclaw Medical University, Wrocław, Poland (Wydział Lekarski / Faculty of Medicine)
3
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu / Wroclaw Medical University, Wrocław, Poland (Uniwersyteckie Centrum Urologii / Department of Urology)
4
Politechnika Wrocławska / Wroclaw University of Science and Technology, Wrocław, Poland (Katedra Nauk Przedklinicznych, Farmakologii i Diagnostyki Medycznej / Department of Preclinical Sciences, Pharmacology, and Medical Diagnostics)
These authors had equal contribution to this work
Online publication date: 2024-07-12
Corresponding author
Małgorzata Szymala-Pędzik
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Katedra i Klinika Geriatrii, ul. Tytusa Chałubińskiego 1a, 50-368 Wrocław
Med Pr Work Health Saf. 2024;75(3):223-31
KEYWORDS
TOPICS
ABSTRACT
Background: Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disorder affecting about 25% of the global population. The causes of its development include poor diet, low physical activity, overweight, obesity, older age, diabetes, and lipid disorders. Non-alcoholic fatty liver disease is identified by some researchers as a hepatic manifestation of metabolic syndrome. It has been observed that patients with NAFLD have an increased risk of cardiovascular events, as well as a higher number of deaths from myocardial infarction compared to the general population. Material and Methods: A retrospective analysis was conducted on the data of 237 patients diagnosed with hepatic steatosis, treated in the Department of Geriatrics at the University Clinical Hospital in Wrocław from 2019 to 2022, focusing on coexisting overweight, obesity, and concomitant diseases. Laboratory results and the degree of left ventricular muscle hypertrophy were analyzed. Parameters assessed by echocardiography, including interventricular septal thickness in diastole (IVSd), left ventricular posterior wall thickness in diastole (LVPWd), and IVSd + LVPWd/2, were used to evaluate left ventricular hypertrophy. Results: Data from 237 patients were analyzed: 79 men (age: 77.2±7.1 years) and 158 women (age: 78.4±7.7 years). Body mass index (BMI) values for men and women were 30.5±5.0 kg/m² and 31.9±5.6 kg/m², respectively. There was a positive correlation between BMI and the degree of left ventricular hypertrophy for the parameters IVSd
(ρ = 0.36, p < 0.001), LVPWd (ρ = 0.36, p < 0.001), and IVSd + LVPWd/2 (ρ = 0.38, p < 0.001). Conclusions: The study demonstrated
a moderate positive correlation between BMI and the degree of left ventricular hypertrophy in patients diagnosed with hepatic
steatosis. These findings indicate the necessity of actively searching for cardiovascular risk factors, including the evaluation of echocardiographic
parameters in patients with NAFLD. Med Pr Work Health Saf. 2024;75(3):223–231