Background: Several studies have shown an association between work-related stress and risk factors for cardiovascular disease. However, only a few studies concerned the police. The aim of this study was to assess the relationship between the general and work-related stress, and the functioning of the circulatory system in the police staff. Material and Methods: The study group consisted of 126 policemen (aged 37.8±7.3 years), with average employment duration of 14.4±7 years. The study comprised the assessment of health status based on the medical examination and medical history of identified diseases, cardiovascular risk factors and symptoms, dietary habits, physical activity, intake of drugs, data on the family history, determinations of serum total cholesterol, HDL and LDL fractions, triglycerides, and fasting glycemia. The stress level was assessed using the Questionnaire for the Subjective Assessment of Work and Perceived Stress Scale. Results: On medical examination hypertension was found in 36% of the people under study. Chest discomfort was reported by 60% of the subjects. Average body mass index (BMI), serum cholesterol and LDL were elevated (22.7±4.1, 222.6±41.7 mg/dl and 142.7±39.7 mg/dl, respectively). Mean triglyceride, HDL fraction and fasting glucose levels were normal in the whole group. The levels of general and occupational stress were 34.9±4.8 and 128.0±33.3, respectively, being higher than in other occupational groups. In the group with the highest level of stress, there were significantly more people with circulatory problems (81%), drinking strong alcohol at least once a week (27%), working in a 3-shift system (40.5%) and working overtime (44%). Conclusions: The results show that the police are a group at high risk of developing cardiovascular diseases due to work-related stress. Med Pr 2013;64(3):335–348