This paper summarizes the currently available knowledge on the impact of infrasound and low frequency noise (LFN) on human health and well-being. This narrative review of the literature data was based on the selected, mostly, peer-reviewed research papers, review articles, and meta-analyses that were published in 1973–2022. It has been focused on infrasound perception, annoyance attributed to infrasound and low-frequency noise, as well as their effects on the cardiovascular system and sleep disorders. Particular attention was also paid to the latest research results and specific sources of infrasound and LFN, i.e., wind turbines. Med Pr Work Health Saf. 2023;74(4):317–32.