Influenza vaccination, as a key element of control activities intended, inter alia, to prevent nosocomial influenza transmission, is recommended each year for all healthcare workers (HCWs). Due to these recommendations and the importance of influenza vaccination among HCWs, a targeted literature review was conducted to assess issues related to vaccination coverage, declared motivators and barriers, as well as interventions to increase vaccination coverage in this professional group. Data obtained from the available publications implies that influenza vaccination rates among WHCs are universally low and vary over time as well as between regions and different types of healthcare professionals (physicians/nurses). One of the main determinants of influenza vaccine uptake is the desire to protect oneself and one’s family. On the other hand, practical considerations and misconceptions about the safety and effectiveness of vaccines are the most frequently mentioned preventative causes. There is an urgent need to implement well-organized educational campaigns as this is key to increasing vaccination rates as part of a non-mandatory vaccination strategy. Med Pr. 2021;72(3):305–19