Background: The aim of the project is to identify the risk of osteoporotic fractures in women aged over 50, the evaluation of FRAX® BMD and FRAX® BMI in women with and without osteoporotic fractures and the proposal of therapeutic starting points for treatment of osteoporosis. Material and Methods: A group of 1014 women aged 50-89, living in the Kujawsko-Pomorskie province, was investigated. The analysis was based on the WHO definition of osteoporosis. Calculations of 10-year absolute risk of major osteoporotic fractures (AR-10 MOF Fx) and femoral neck fractures (AR-10 FN Fx) were done using Polish 3.3 version of FRAX® tool. The analysis of fracture risk employed the logistic regression method. Results: A statistically significant relationship was found between the risk of osteoporotic fractures and age, femoral neck BMD, a history of previous osteoporotic fractures, estimated calcaneal BMD and vertebral column BMD. The differences between 10-year absolute risk of major osteoporotic fractures BMD and BMI was small, which means that FRAX® BMI might be a useful tool for GPs and occupational medicine specialists. Conclusions: A high usefulness of the FRAX® BMI tool for evaluating the risk of major osteoporotic fractures provide a new possibility of identifying women at risk of such events. The mean value of 10-year absolute risk of major osteoporotic fractures for FRAX® BMD and BMI was identified as 10% and 12%, respectively and these values were proposed as therapeutic starting points for treatment of osteoporosis in women living in the Kujawsko-Pomorskie province. Med Pr 2013;64(3):327–333