The increasing number of cases of tick-borne encephalitis (TBE) reported in recent years in Europe and, more recently, in Poland is a consequence of factors related to climate and environmental change leading to increasing tick populations and human behavior favoring exposure. In Poland, there is considerable regional variation in the incidence of TBE, resulting, among other factors, from underreporting of all cases and limited access to laboratory diagnostics. The consequence is low public awareness of the disease and insufficient use of vaccination as optimal prevention. The current system of surveillance for TBE in Poland needs to be improved: the introduction of standardised standards of clinical practice and wider access to laboratory. Med Pr Work Health Saf. 2024;75(6):569–582