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REVIEW PAPER
Toxicity of acrylamide and its metabolite – Glicydamide
 
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Uniwersytet Łódzki / University of Łódź, Łódź, Poland (Katedra Biofizyki Skażeń Środowiska, Wydział Biologii i Ochrony Środowiska / Department of Environmental Pollution Biophysics, Faculty of Biology and Environmental Protection)
CORRESPONDING AUTHOR
Daria Pingot   

Katedra Biofizyki Skażeń Środowiska, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki, ul. Pomorska 141/143, 90-236 Łódź
 
Med Pr 2013;64(2):259–271
 
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ABSTRACT
Acrylamide is a synthetic chemical compound commonly used in many branches of industry. It is mainly used in the synthesis of polyacrylamides, which are widely employed in plastics, paints, varnishes, adhesives and mortars production. Acrylamide is also applied in the cellulose-paper and cosmetic industries to produce toiletries and cosmetics. The interest in acrylamide increased in 2002, when Swedish scientists showed that a considerable amount of this substance is formed during frying and baking of various foods. Studies concerning toxicity of acrylamide and its metabolite - glicydamide showed their neurotoxic, genotoxic and carcinogenic effects. Neverthless, in humans only neurotoxic effect of acrylamide has been clearly evidenced. Genotoxic nature of acetylamide manifests itself mainly in its metabolic conversion to the epoxide derivative glicydamide. Carcinogenic effects of acrylamide have been shown in animal studies. Epidemiological studies have not provided explicit evidence that acrylamide supplied with the diet can initiate the formation of tumors in humans. Acrylamide exposure is assessed by measuring specific compounds (adducts) formed during the reaction of acrylamide with hemoglobin and DNA. Med Pr 2013;64(2):259–271
eISSN:2353-1339
ISSN:0465-5893