Lead-elevated activity of xanthine oxidase in lead-exposed workers
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Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach, Zabrze, Poland (Department of Biochemistry, School of Medicine with the Division of Dentistry / Zakład Biochemii Ogólnej, Katedra Biochemii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym)
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach, Sosnowiec, Poland (Department of Biophysics, School of Pharmacy with the Division of Laboratory Medicine / Katedra i Zakład Biofizyki, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej)
Eko-Prof-Med Medical Centre / Centrum Medyczne Eko-Prof-Med, Miasteczko Śląskie, Poland
Independent Public Health Care Centre in Staszów / Samodzielny Publiczny Zespół Zakładów Opieki Zdrowotnej w Staszowie, Staszów, Poland (Department of Internal Medicine / Oddział Chorób Wewnętrznych)
Corresponding author
Sławomir Kasperczyk   

Department of Biochemistry, Medical University of Silesia, Jordana 19, 41-808 Zabrze
Med Pr 2013;64(2):175–180
Background: The aim of the present study was to explore the connection between lead toxicity and the activity of xanthine oxidase (XO). In addition, we indicated the uric acid (UA) and creatinine levels and concentration of erythrocyte malondialdehyde (MDA) to estimate oxidative stress intensity. Materials and Methods: The examined group consisted of 125 healthy male employees of zinc and lead works. The examined group was divided into tertiles according to blood lead levels. In the collected blood samples, concentrations of lead-exposure indices, UA, creatinine, and MDA as well as activity of XO were measured concomitantly. The control group consisted of 32 healthy male administrative workers who were exposed to lead only environmentally. Results: XO activity and MDA level were significantly elevated in all tertiles compared to the control group. Creatinine level was significantly elevated in the medium and high tertiles. However, the level of UA was significantly elevated in the high tertile, while in the low and medium tertile only a tendency toward higher values was observed. Conclusions: Occupational exposure to lead induces activity of XO. This induction may contribute to the observed simultaneously increased oxidative stress, measured as MDA level, and the increased level of UA. Med Pr 2013;64(2):175–180