REVIEW PAPER
Ethylene glycol and propylene glycol ethers – Reproductive and developmental toxicity
 
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Collegium Medicum Uniwersytetu Jagiellońskiego / Jagiellonian University Medical College, Kraków, Poland (Wydział Farmaceutyczny, Zakład Biochemii Toksykologicznej / Faculty of Pharmacy, Department of Biochemical Toxicology)
CORRESPONDING AUTHOR
Beata Starek-Świechowicz   

Collegium Medicum Uniwersytetu Jagiellońskiego, Wydział Farmaceutyczny, Zakład Biochemii Toksykologicznej, ul. Medyczna 8, 30-688 Kraków
 
Med Pr 2015;66(5):725–737
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ABSTRACT
Both ethylene and propylene glycol alkyl ethers (EGAEs and PGAEs, respectively) are widely used, mainly as solvents, in industrial and household products. Some EGAEs demonstrate gonadotoxic, embriotoxic, fetotoxic and teratogenic effects in both humans and experimental animals. Due to the noxious impact of these ethers on reproduction and development of organisms EGAEs are replaced for considerably less toxic PGAEs. The data on the mechanisms of testicular, embriotoxic, fetotoxic and teratogenic effects of EGAEs are presented in this paper. Our particular attention was focused on the metabolism of some EGAEs and their organ-specific toxicities, apoptosis of spermatocytes associated with changes in the expression of various genes that code for oxidative stress factors, protein kinases and nuclear hormone receptors. Med Pr 2015;66(5):725–737
eISSN:2353-1339
ISSN:0465-5893