Haff disease – are we threatened with another epidemic?
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Gdański Uniwersytet Medyczny / Medical University of Gdansk, Gdańsk, Poland (Klinika Chorób Zawodowych, Metabolicznych i Wewnętrznych / Department of Occupational, Metabolic and Internal Diseases)
Niepubliczny Zakład Opieki Zdrowotnej Centrum Chorób Wewnętrznych „El-Vita” Sp. z o.o. / Non-public Health Care Facility Internal Medicine Center “El-Vita” Ltd., Elbląg, Poland (Oddział Chorób Wewnętrznych z Pododdziałem Nefrologii i Stacją Dializ / Internal Medicine Department with the Nephrology Division and Dialysis Station)
Online publication date: 2021-09-03
Corresponding author
Przemysław Paul   

Gdański Uniwersytet Medyczny, Klinika Chorób Zawodowych, Metabolicznych i Wewnętrznych, ul. Powstania Styczniowego 9b, 81-519 Gdynia
Med Pr 2021;72(5):605–610
Haff disease is a group of symptoms caused by rhabdomyolysis following ingestion of some species of fish and crayfish. Pathophysiology remains unknown. Outbreaks of the Haff disease have been reported in many regions of the world. In this article we present the case of a 38-years-old patient, professional fisherman, suspected of suffering from Haff disease. He developed symptoms of diffuse myalgia, headache, chest pressure, brown-colored urine and elevated blood pressure. Predominant laboratory abnormalities were elevated serum creatine kinase and creatinine concentrations. During hospitalization the patient required the renal replacement therapy. As a result of applied procedures, clinical and laboratory improvement was achieved. The patient was discharged home in good general condition. The Haff disease should be included in the differential diagnosis of rhabdomyolysis. Detailed medical interview, especially questions about recently consumed food and occupational exposure, is crucial in making a proper diagnosis. Med Pr. 2021;72(5):605–10