Lead hepatotoxicity: Selected aspects of pathobiochemistry

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie / Warsaw University of Life Sciences - SGGW, Warszawa, Poland (Katedra Biochemii / Department of Biochemistry)

Corresponding author

Mateusz Labudda

Katedra Biochemii, Wydział Rolnictwa i Biologii, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159, 02-776 Warszawa

Med Pr Work Health Saf. 2013;64(4):565-8

DOI: https://doi.org/10.13075/mp.5893.2013.0040

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ABSTRACT

Lead (Pb) that belongs to heavy metals is one of the major pollution components of the environment. Occupational and environmental exposure to lead can cause its absorption by the body and consequently exert toxic effects in the liver. In this paper biochemical determinants of hepatotoxicity caused by lead are presented. Generation of reactive oxygen species, disturbances in the cellular antioxidant system, lipid peroxidation, inhibition of enzymatic proteins and intercellular signaling are also discussed. Med Pr 2013;64(4):565–568

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