Background: The way the municipal transport drivers perform their job contributes to varied burdens linked with the body posture at work, stress, shift work, vibration, noise and exposure to chemical agents. The aim of the study was to assess the condition of the nervous system (NS) in municipal transport drivers. Material and Methods: The study covered 42 men, aged 43.4 years (standard deviation (SD): 8.3), employed as bus drivers in the municipal transport enterprise. The duration of employment was 11.8 years on average (SD: 8.6). The condition of the nervous system was assessed on the basis of clinical neurological examinations. Results: Chronic lumbosacral syndrome was found in 54.8% of the subjects. A significant relationship between the incidence of lumbosacral syndrome and the duration of employment (p = 0.032) was observed; significantly higher in drivers employed for 11–15 years (90.9%) in comparison to the remaining groups. Nervous system functional disorders were niejedcharacterized by the increased emotional irritability (47.6%), sleep disorders manifested by excessive sleepiness (33.3%) or insomnia (28.6%) and headaches (3%), mostly tension headaches. Excessive daytime sleepiness was significantly age-dependent (p = 0.038). Conclusions: The evidenced NS disorders indicate the need to undertake preventive measures tailored for the occupational group of bus drivers. Med Pr 2015;66(3):333–341