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ORIGINAL PAPER
 
CC BY-NC 3.0 Polska
 
 

Monoinfections caused by Borrelia burgdorferi and Borrelia burgdorferi / Anaplasma phagocytophilum co-infections in forestry workers and farmers

Anna Pańczuk 1,  
Dorota Plewik 2,  
 
1
Państwowa Szkoła Wyższa im. Papieża Jana Pawła II / Pope John Paul II State School of Higher Education, Biała Podlaska, Poland (Katedra Zdrowia / Departament of Health)
2
Państwowa Szkoła Wyższa im. Papieża Jana Pawła II / Pope John Paul II State School of Higher Education, Biała Podlaska, Poland (Centrum Badań nad Innowacjami / Innovation Research Centre)
Med Pr 2015;66(5):645–651
KEYWORDS:
TOPICS:
ABSTRACT:
Background: The presence of co-infections induced by tick-borne pathogens in humans is an important epidemiological phenomenon. This issue has attracted growing attention of doctors and people working under conditions of an increased risk of being exposed to tick bites. Material and Methods: The research group consisted of 93 individuals with current anti-immunoglobulin M/G (IgM/ IgG) Borrelia burgdorferi or IgG anti-Anaplasma phagocytophilum. The respondents were identified during the screening survey in a group of farmers and foresters occupationally exposed to tick bites. The aim of the work was to analyse the frequency of antibodies to specific antigens of B. burgdorferi and the levels of cytokines in forestry workers and farmers with B. burgdorferi monoinfections and B. burgdorferi / A. phagocytophilum co-infections. Statistical analysis was performed using the Chi2, Mann-Whitney U and Kruskal-Wallis tests. Results: There is a stronger generation of IgG antibodies to B. burgdorferi antigens in patients with B. burgdorferi / A. phagocytophilum co-infections, such as variable major protein-like sequence expressed (VlsE) (p < 0.05), p19 (p < 0.02), p17 (p < 0.05) and complement regulator-acquiring surface protein 3 (CRASP3) (p < 0.02) compared to persons with B. burgdorferi monoinfections. The discrepancies in the synthesis of cytokines interleukin 6 (IL-6), IL-10, and tumor necrosis factor α (TNF-α) have not been found in persons with B. burgdorferi monoinfections and B. burgdorferi / A. phagocytophilum co-infection. Conclusions: The immune response directed against B. burgdorferi is stronger in patients co-infected with B. burgdorferi and A. phagocytophilum than in those with monoinfection. Med Pr 2015;66(5):645–651
CORRESPONDING AUTHOR:
Małgorzata Tokarska-Rodak   
Państwowa Szkoła Wyższa im. Papieża Jana Pawła II, Katedra Zdrowia, ul. Sidorska 102, 21-500 Biała Podlaska
eISSN:2353-1339
ISSN:0465-5893