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ORIGINAL PAPER
 
CC BY-NC 3.0 Polska
 
 

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

Recep Dokuyucu 1  ,  
Ali Bilgili 2,  
Basak Hanedan 3,  
Hatice Dogan 1,  
 
1
Mustafa Kemal University, Hatay, Turkey (Faculty of Medicine, Department of Physiology)
2
Ankara University, Ankara, Turkey (Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology)
3
Ataturk University, Erzurum, Turkey (Faculty of Veterinary Medicine, Department of Internal Medicine)
4
Lumina – The University of South-East Europe, Bucharest, Romania (Faculty of Mathematics and Computer Science, Department of Information Technology)
5
Mustafa Kemal University, Hatay, Turkey (Faculty of Medicine, Department of Internal Medicine)
Med Pr 2016;67(6):743–749
KEYWORDS:
TOPICS:
ABSTRACT:
Background: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 μmol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats’ plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis. Med Pr 2016;67(6):743–749
CORRESPONDING AUTHOR:
Recep Dokuyucu   
Mustafa Kemal University, Faculty of Medicine, Department of Physiology, Hatay Street 2, Serinyol, 31040 Antakya, Hatay, Turkey
eISSN:2353-1339
ISSN:0465-5893